Preliminary evaluation of cytotoxic properties of Raphia hookeri fruit mesocarp

The aqueous and n-butanol fractions of the methanolic extract of Raphia hookeri fruit mesocarp was evaluated for cytotoxic properties using three different bioassays. The n-butanol fraction exhibited greater cytotoxicity than the aqueous fraction when tested against brine shrimp, mosquito larvae, an...

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Bibliographic Details
Published in:Fitoterapia 2000-04, Vol.71 (2), p.190-192
Main Authors: Obuotor, E.M, Onajobi, F.D
Format: Article
Language:English
Subjects:
Animals
Artemia - drug effects
Bufonidae
Culex - drug effects
Cytotoxicity
Fruit
Larva - drug effects
Plant Extracts - toxicity
Plants, Medicinal
Raphia hookeri
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Summary:The aqueous and n-butanol fractions of the methanolic extract of Raphia hookeri fruit mesocarp was evaluated for cytotoxic properties using three different bioassays. The n-butanol fraction exhibited greater cytotoxicity than the aqueous fraction when tested against brine shrimp, mosquito larvae, and 5-day old tadpoles, the cytotoxicity towards the tadpoles being the most pronounced (LC 50=0.83 ppm).
ISSN:0367-326X
DOI:10.1016/S0367-326X(99)00136-7