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The effect of lamotrigine on naloxone-precipitated opiate withdrawal

We hypothesized that lamotrigine, a putative glutamate release antagonist, would attenuate glutamate-mediated signs of opiate withdrawal. Seven heroin-dependent subjects were hospitalized, stabilized on oral levorphanol 6 mg three times daily, and thrice underwent withdrawal precipitated by naloxone...

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Bibliographic Details
Published in:Drug and alcohol dependence 1998-10, Vol.52 (2), p.173-176
Main Authors: Rosen, Marc I, Rowland Pearsall, H, R. Kosten, Thomas
Format: Article
Language:English
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Summary:We hypothesized that lamotrigine, a putative glutamate release antagonist, would attenuate glutamate-mediated signs of opiate withdrawal. Seven heroin-dependent subjects were hospitalized, stabilized on oral levorphanol 6 mg three times daily, and thrice underwent withdrawal precipitated by naloxone 0.4 mg intravenously. Lamotrigine (placebo, 250 mg, and 500 mg) was randomly given as a pretreatment 6 h before naloxone. Lamotrigine did not significantly attenuate any measure of opiate withdrawal. Lamotrigine was well-tolerated in subjects, although one did develop an allergic rash.
ISSN:0376-8716
1879-0046
DOI:10.1016/S0376-8716(98)00057-X