New electron-capture gas-liquid chromatographic method for the determination of mexiletine plasma levels in man

A method for the determination of mexiletine in human plasma by gas—liquid chromatography with electron-capture detection is described. Plasma samples are extracted at pH 12 with dichloromethane after addition of the internal standard, the 2,4-methyl analogue of mexiletine. A derivative is obtained...

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Bibliographic Details
Published in:Journal of chromatography. Biomedical applications 1978-05, Vol.145 (3), p.401-411
Main Authors: Frydman, Armand, Lafarge, Jean-Pierre, Vial, François, Rulliere, Roger, Alexandre, Jean-Michel
Format: Article
Language:English
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Summary:A method for the determination of mexiletine in human plasma by gas—liquid chromatography with electron-capture detection is described. Plasma samples are extracted at pH 12 with dichloromethane after addition of the internal standard, the 2,4-methyl analogue of mexiletine. A derivative is obtained using heptafluorobutyric anhydride; according to gas chromatography—mass spectrometry it is a monoheptafluorobutyryl compound. The minimum detectable amount of mexiletine is 5 pg. Accurate determinations of human plasma levels were performed after oral or intravenous treatment.
ISSN:0378-4347
DOI:10.1016/S0378-4347(00)81369-9