The enhancement of the bioadhesive properties of calcium alginate gel beads by coating with chitosan

Alginate-chitosan microcapsules have been investigated as a bioadhesive drug delivery system. Calcium alginate gel beads uncoated and coated with chitosan were tested for adhesive properties, using novel techniques, with negatively charged chromatography particles and in vitro with pig oesophagus an...

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Bibliographic Details
Published in:International journal of pharmaceutics 1998-12, Vol.175 (2), p.237-246
Main Authors: Gåserød, Olav, Jolliffe, Ian G., Hampson, Frank C., Dettmar, Peter W., Skjåk-Bræk, Gudmund
Format: Article
Language:English
Subjects:
Alginate
Bioadhesion
Biological and medical sciences
Chitosan
General pharmacology
Medical sciences
Microcapsules
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
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Summary:Alginate-chitosan microcapsules have been investigated as a bioadhesive drug delivery system. Calcium alginate gel beads uncoated and coated with chitosan were tested for adhesive properties, using novel techniques, with negatively charged chromatography particles and in vitro with pig oesophagus and stomach mucosa. The addition of a chitosan coating increased the adhesive properties significantly. The adherence of both coated and uncoated beads was much greater to the stomach mucosa than to oesophageal mucosa. The difference in adhesive properties between the coated and uncoated microcapsules was also found considerably larger for the stomach mucosa. The homogeneity of the alginate gel core as measured by the alginate concentration gradient through the cross section of the beads also influenced the adhesive properties with homogeneous capsules adhering better than the inhomogeneous capsules.
ISSN:0378-5173
1873-3476
DOI:10.1016/S0378-5173(98)00277-4