Biodistribution of fluoresceinated dextran using novel nanoparticles evading reticuloendothelial system

The rapid clearance of circulating nanoparticles from the blood stream coupled with their high uptake by liver and spleen has thus far been overcome by reducing the particle size, and by making the particle surface hydrophilic with poloxamers and poloxamines. We have prepared hydrogel nanoparticles...

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Bibliographic Details
Published in:International journal of pharmaceutics 2000-07, Vol.202 (1), p.1-10
Main Authors: Gaur, Upasna, Sahoo, Sanjeeb Kumar, De, Tapas K, Ghosh, Prahlad C, Maitra, Amarnath, Ghosh, P.K
Format: Article
Language:English
Subjects:
Animals
Anticoagulants - pharmacokinetics
Biological and medical sciences
Dextrans - pharmacokinetics
Drug targeting
Fluoresceins - pharmacokinetics
Fluorescent Dyes - pharmacokinetics
General pharmacology
Hydrogel nanoparticles
Hydrogels - pharmacokinetics
Kidney - metabolism
Long circulating nanoparticles
Male
Medical sciences
Mice
Mononuclear Phagocyte System - metabolism
Particle Size
Pharmaceutic Aids - pharmacokinetics
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Polyvinylpyrrolidone
Povidone - pharmacokinetics
RES evasion
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Summary:The rapid clearance of circulating nanoparticles from the blood stream coupled with their high uptake by liver and spleen has thus far been overcome by reducing the particle size, and by making the particle surface hydrophilic with poloxamers and poloxamines. We have prepared hydrogel nanoparticles of polyvinylpyrrolidone of a size less than 100 nm diameter with precise size distribution. Since the inner cores of these particles are also hydrophilic, these particles are capable of encapsulating water-soluble compounds. Biodistribution of these particles shows practically negligible (
ISSN:0378-5173
1873-3476
DOI:10.1016/S0378-5173(99)00447-0