Effect of Kombucha tea on chromate(VI)-induced oxidative stress in albino rats

The effect of Kombucha tea (KT) on oxidative stress induced changes in rats subjected to chromate treatment are reported. KT feeding alone did not show any significant change in malondialdehyde (MDA) and reduced glutathione (GSH) levels, but did enhance humoral response and delayed type of hypersens...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2000-07, Vol.71 (1), p.235-240
Main Authors: Sai Ram, M, B, Anju, T, Pauline, Prasad, Dipti, Kain, A.K, Mongia, S.S, Sharma, S.K, Singh, B, Singh, R, Ilavazhagan, G, Kumar, Devendra, Selvamurthy, W
Format: Article
Language:English
Subjects:
Animals
Antibody Formation - drug effects
Antioxidants - pharmacology
Beverages - analysis
Biological and medical sciences
Chromate
Chromates - antagonists & inhibitors
Chromates - toxicity
Erythrocytes - immunology
Fermentation
General pharmacology
Glutathione - blood
Hypersensitivity, Delayed - immunology
Immunity
Kombucha tea
Liver - drug effects
Liver - metabolism
Male
Malondialdehyde - blood
Medical sciences
Oxidative stress
Oxidative Stress - drug effects
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Rats
Rats, Sprague-Dawley
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Summary:The effect of Kombucha tea (KT) on oxidative stress induced changes in rats subjected to chromate treatment are reported. KT feeding alone did not show any significant change in malondialdehyde (MDA) and reduced glutathione (GSH) levels, but did enhance humoral response and delayed type of hypersensitivity (DTH) response appreciably over control animals. Chromate treatment significantly enhanced plasma and tissue MDA levels, decreased DTH response considerably, enhanced glutathione peroxidase and catalase activities; however, no change in GSH, superoxide dismutase and antibody titres was noticed. KT feeding completely reversed the chromate-induced changes. These results show that Kombucha tea has potent anti-oxidant and immunopotentiating activities.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(00)00161-6