Hepatoprotective activity of Emblica officinalis and Chyavanaprash

Hepatoprotective activity of Emblica officinalis (EO) and Chyavanaprash (CHY) extracts were studied using carbon tetrachloride (CCl 4) induced liver injury model in rats. EO and CHY extracts were found to inhibit the hepatotoxicity produced by acute and chronic CCl 4 administration as seen from the...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2000-09, Vol.72 (1), p.135-140
Main Authors: Jose, Jeena K, Kuttan, Ramadasan
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Carbon Tetrachloride Poisoning - prevention & control
Chemical and Drug Induced Liver Injury - prevention & control
Chyavanaprash
Collagen - metabolism
Emblica officinalis
General pharmacology
Hepatoprotection
Herbal drugs
Hydroxyproline - metabolism
India
Lipid Peroxidation - drug effects
Liver Cirrhosis, Experimental - chemically induced
Liver Cirrhosis, Experimental - prevention & control
Liver Function Tests
Male
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - therapeutic use
Plants, Medicinal - chemistry
Rats
Rats, Wistar
Thiobarbituric Acid Reactive Substances - metabolism
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Summary:Hepatoprotective activity of Emblica officinalis (EO) and Chyavanaprash (CHY) extracts were studied using carbon tetrachloride (CCl 4) induced liver injury model in rats. EO and CHY extracts were found to inhibit the hepatotoxicity produced by acute and chronic CCl 4 administration as seen from the decreased levels of serum and liver lipid peroxides (LPO), glutamate-pyruvate transaminase (GPT), and alkaline phosphatase (ALP). Chronic CCl 4 administration was also found to produce liver fibrosis as seen from the increased levels of collagen-hydroxyproline and pathological analysis. EO and CHY extracts were found to reduce these elevated levels significantly, indicating that the extract could inhibit the induction of fibrosis in rats.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(00)00219-1