Antimicrobial, antioxidant, antitumour-promoting and cytotoxic activities of different plant part extracts of Garcinia atroviridis Griff. ex T. Anders

Crude extracts (methanol) of various parts, viz. the leaves, fruits, roots, stem and trunk bark, of Garcinia atroviridis were screened for antimicrobial, cytotoxic, brine shrimp toxic, antitumour-promoting and antioxidant activities. The crude extracts exhibited predominantly antibacterial activity...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2000-10, Vol.72 (3), p.395-402
Main Authors: Mackeen, M.M, Ali, A.M, Lajis, N.H, Kawazu, K, Hassan, Z, Amran, M, Habsah, M, Mooi, L.Y, Mohamed, S.M
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Anticarcinogenic Agents - pharmacology
Antimicrobial
Antineoplastic Agents, Phytogenic - pharmacology
Antioxidant
Antitumour-promoting
Biological and medical sciences
Cell Line
Decapoda (Crustacea)
Garcinia atroviridis
General pharmacology
Humans
Medical sciences
Microbial Sensitivity Tests
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Rosales - chemistry
Toxicity Tests
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Summary:Crude extracts (methanol) of various parts, viz. the leaves, fruits, roots, stem and trunk bark, of Garcinia atroviridis were screened for antimicrobial, cytotoxic, brine shrimp toxic, antitumour-promoting and antioxidant activities. The crude extracts exhibited predominantly antibacterial activity with the root extract showing the strongest inhibition against the test bacteria at a minimum inhibitory dose (MID) of 15.6 μg/disc. Although all the extracts failed to inhibit the growth of most of the test fungi, significant antifungal activity against Cladosporium herbarum was exhibited by most notably the fruit (MID: 100 μg), and the leaf (MID: 400 μg) extracts. None of the extracts were significantly cytotoxic, and lethal towards brine shrimps. The root, leaf, trunk and stem bark extracts (except for the fruits) showed strong antioxidant activity exceeding that of the standard antioxidant, α-tocopherol. Antitumour-promoting activity (>95% inhibition) was shown by the fruit, leaf, stem and trunk bark extracts.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(00)00245-2