Antidiarrhoeal and antiulcerogenic effects of methanolic extract of Asparagus pubescens root in rats

The effect of methanolic extract of Asparagus pubescens root on experimentally-induced diarrhoea and ulceration was investigated in rats. The extract (500–1500 mg/kg) dose-dependently, reduced significantly the intestinal propulsive movement, castor oil-induced diarrhoea and intestinal fluid accumul...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2000-10, Vol.72 (3), p.421-427
Main Authors: Nwafor, Paul A., Okwuasaba, F.K., Binda, L.G.
Format: Article
Language:English
Subjects:
Anti-Ulcer Agents - pharmacology
Antidiarrheals - pharmacology
Antidiarrhoeal
Antiulcer
Asparagus pubescens root
Biological and medical sciences
Gastrointestinal Motility - drug effects
General pharmacology
Indomethacin - adverse effects
Liliaceae - chemistry
Medical sciences
Methanol - chemistry
Methanolic extract
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Plant Roots - chemistry
Stomach Ulcer - chemically induced
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Summary:The effect of methanolic extract of Asparagus pubescens root on experimentally-induced diarrhoea and ulceration was investigated in rats. The extract (500–1500 mg/kg) dose-dependently, reduced significantly the intestinal propulsive movement, castor oil-induced diarrhoea and intestinal fluid accumulation. Yohimbine an α 2-adrenoceptor blocker attenuated the antidiarrhoeal effect of the extract. The extract also reduced the ulcer indices induced by indomethacin and ethanol in a dose-related manner. The results indicate that its antidiarrhoeal and antiulcerogenic effects might in part be due to its α 2-adrenoceptor stimulation and its active constituents respectively.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(00)00261-0