Extracts of Benincasa hispida prevent development of experimental ulcers

Benincasa hispida ( B. hispida) is recommended in Ayurveda for the management of peptic ulcers. Therefore, anti-ulcerogenic activity of different extracts of B. hispida (fresh juice, supernatant and residue fraction of centrifuged juice, alcoholic and petroleum ether extract) were studied in aspirin...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2001-12, Vol.78 (2), p.159-164
Main Authors: Grover, J.K, Adiga, G, Vats, V, Rathi, S.S
Format: Article
Language:English
Subjects:
Animals
Anti-Ulcer Agents - isolation & purification
Anti-Ulcer Agents - therapeutic use
Anti-Ulcer Agents - toxicity
Ayurveda
Benincasa cerifera
Benincasa hispida
Biological and medical sciences
Cucurbitaceae
Experimental ulcers
Fruit
General pharmacology
India
Male
Medical sciences
Medicine, Ayurvedic
Mice
Peptic Ulcer - prevention & control
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - isolation & purification
Plant Extracts - therapeutic use
Plant Extracts - toxicity
Ranitidine - therapeutic use
Rats
Swimming
Traditional medicine
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Summary:Benincasa hispida ( B. hispida) is recommended in Ayurveda for the management of peptic ulcers. Therefore, anti-ulcerogenic activity of different extracts of B. hispida (fresh juice, supernatant and residue fraction of centrifuged juice, alcoholic and petroleum ether extract) were studied in aspirin plus restraint, swimming stress, indomethacin plus histamine and serotonin-induced ulcers in rats and mice. The oral feeding of different doses of the extract significantly reduced the ulcer index produced by various ulcerogens. The anti-ulcerogenic effect was dose-dependent in stress induced model of ulcer and not in other models. B. hispida probably has a CNS component in prevention of stress induced ulceration. However, antihistaminic, anti-cholinergic effects and prevention of disturbance in gastric micro-circulation as possible modes of action cannot be ruled out. Chronic toxicity studies carried out for 3 months revealed no deleterious effect of fresh juice of B. hispida on various hematological and biochemical parameters studied. Thus, extracts of B. hispida may be considered to be a drug of natural origin possessing anti-ulcer activity.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(01)00334-8