Effect of Acanthopanax senticosus stem on mast cell-dependent anaphylaxis

We studied the effect of Acanthopanax senticosus stem (ACPS) on mast cell-dependent anaphylaxis. ACPS inhibited compound 48/80-induced systemic anaphylaxis at a dose of 1.0 g/kg by 50%. ACPS also inhibited passive cutaneous anaphylaxis reaction and histamine release from mast cells in a dose-depende...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2002-03, Vol.79 (3), p.347-352
Main Authors: YI, Jin-Mu, HONG, Seung-Heon, KIM, Jong-Ha, KIM, Hyeong-Kyun, SONG, Ho-Joon, KIM, Hyung-Min
Format: Article
Language:English
Subjects:
Anaphylaxis - chemically induced
Anaphylaxis - drug therapy
Anaphylaxis - immunology
Animals
Biological and medical sciences
Dose-Response Relationship, Drug
Eleutherococcus - physiology
General pharmacology
Mast Cells - drug effects
Mast Cells - immunology
Medical sciences
Mice
Mice, Inbred ICR
p-Methoxy-N-methylphenethylamine - pharmacology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Stems - physiology
Rats
Rats, Sprague-Dawley
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Summary:We studied the effect of Acanthopanax senticosus stem (ACPS) on mast cell-dependent anaphylaxis. ACPS inhibited compound 48/80-induced systemic anaphylaxis at a dose of 1.0 g/kg by 50%. ACPS also inhibited passive cutaneous anaphylaxis reaction and histamine release from mast cells in a dose-dependent manner, respectively. Moreover, ACPS had an inhibitory effect on anti-dinitrophenyl IgE-induced tumor necrosis factor-alpha (TNF-alpha) production from mast cells. These results indicate that ACPS inhibits mast cell-mediated anaphylaxis in vivo and in vitro murine model.
ISSN:0378-8741
1872-7573
DOI:10.1016/s0378-8741(01)00403-2