Pharmacological effects of lavandulifolioside from Leonurus cardiaca

Lavandulifolioside was detected for the first time in Leonurus cardiaca var. vulgaris [Moench] Briquet (Lamiaceae). The isolation was performed from the butanolic extract of the aerial parts and the identification by NMR and MS. The pharmacological properties of lavandulifolioside consist of signifi...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2002-04, Vol.80 (1), p.85-90
Main Authors: MIŁKOWSKA-LEYCK, Katarzyna, FILIPEK, Barbara, STRZELECKA, Halina
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood Pressure - drug effects
Depression, Chemical
Electrocardiography - drug effects
General pharmacology
Heart Rate - drug effects
Lamiaceae - chemistry
Lethal Dose 50
Male
Medical sciences
Mice
Motor Activity - drug effects
Oligosaccharides - isolation & purification
Oligosaccharides - pharmacology
Oligosaccharides - toxicity
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Extracts - toxicity
Rats
Rats, Wistar
Time Factors
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Summary:Lavandulifolioside was detected for the first time in Leonurus cardiaca var. vulgaris [Moench] Briquet (Lamiaceae). The isolation was performed from the butanolic extract of the aerial parts and the identification by NMR and MS. The pharmacological properties of lavandulifolioside consist of significant negative chronotropism, prolongation of the P-Q, Q-T intervals and QRS complex, and decrease of blood pressure. Contrary to the butanolic extract lavandulifolioside did not reduce the spontaneous locomotor activity. In conclusion, the pharmacological pattern of lavandulifolioside did not explain the pharmacological effects of L. cardiaca L. alone.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(02)00016-8