Gastroprotective effect of fenugreek seeds ( Trigonella foenum graecum) on experimental gastric ulcer in rats

The effect of fenugreek seeds ( Trigonella foenum graecum) compared to omeprazole was studied on ethanol-induced gastric ulcer. The aqueous extract and a gel fraction isolated from the seeds showed significant ulcer protective effects. The cytoprotective effect of the seeds seemed to be not only due...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2002-08, Vol.81 (3), p.393-397
Main Authors: Suja Pandian, R, Anuradha, C.V, Viswanathan, P
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Ethanol - pharmacology
Gastric Mucosa - drug effects
Gastric Mucosa - metabolism
Gastric Mucosa - pathology
Gastroprotection
General pharmacology
Hydrochloric Acid - pharmacology
Lipid Peroxidation - drug effects
Medical sciences
Omeprazole - pharmacology
Omeprazole - therapeutic use
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phytotherapy
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Rats
Rats, Wistar
Seed extract
Seeds - chemistry
Stomach Ulcer - chemically induced
Stomach Ulcer - metabolism
Stomach Ulcer - pathology
Stomach Ulcer - prevention & control
Thiobarbituric Acid Reactive Substances - metabolism
Trigonella - chemistry
Trigonella foenum graecum
Ulcer inhibition
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Summary:The effect of fenugreek seeds ( Trigonella foenum graecum) compared to omeprazole was studied on ethanol-induced gastric ulcer. The aqueous extract and a gel fraction isolated from the seeds showed significant ulcer protective effects. The cytoprotective effect of the seeds seemed to be not only due to the anti-secretory action but also to the effects on mucosal glycoproteins. The fenugreek seeds also prevented the rise in lipid peroxidation induced by ethanol presumably by enhancing antioxidant potential of the gastric mucosa thereby lowering mucosal injury. Histological studies revealed that the soluble gel fraction derived from the seeds was more effective than omeprazole in preventing lesion formation. These observations show that fenugreek seeds possess antiulcer potential.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(02)00117-4