Antioxidant and analgesic activities of turpentine of Pinus nigra Arn. subsp. pallsiana (Lamb.) Holmboe

The aim of this study is to examine possible antioxidant and analgesic activities of turpentine exudes from Pinus nigra Arn. subsp. pallsiana (Lamb.) Holmboe (TPN). Total antioxidant activity, reducing power, superoxide anion radical scavenging, free radical scavenging, metal chelating, and hydrogen...

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Published in:Journal of ethnopharmacology 2003-05, Vol.86 (1), p.51-58
Main Authors: Gülçin, İlhami, Büyükokuroǧlu, M.Emin, Oktay, Münir, Küfrevioǧlu, Ö.İrfan
Format: Article
Language:English
Subjects:
Analgesic activity
Analgesics - pharmacology
Animals
Antioxidant activity
Antioxidants - pharmacology
Biological and medical sciences
Drug Interactions
Female
General pharmacology
In vitro
In vivo
Male
Medical sciences
Mice
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Pinus
Pinus nigra
Turpentine
Turpentine - pharmacology
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Summary:The aim of this study is to examine possible antioxidant and analgesic activities of turpentine exudes from Pinus nigra Arn. subsp. pallsiana (Lamb.) Holmboe (TPN). Total antioxidant activity, reducing power, superoxide anion radical scavenging, free radical scavenging, metal chelating, and hydrogen peroxide scavenging activities were studied. The total antioxidant activity increased with the increasing amount of extracts (100, 300, and 500 μg) added to linoleic acid emulsion. All of the doses of TPN showed higher antioxidant activity than α-tocopherol. The samples showed 49, 70, and 91% inhibition on peroxidation of linoleic acid emulsion, respectively. On the other hand, the 300 μg of α-tocopherol showed 40% inhibition on peroxidation of linoleic acid emulsion. There is correlation between antioxidant activity and the reducing power, superoxide anion radical scavenging, free radical scavenging, metal chelating, and hydrogen peroxide scavenging activities. Like antioxidant activity, the reducing power, superoxide anion radical scavenging, free radical scavenging, metal chelating, and hydrogen peroxide scavenging activities of TPN depending on concentration and increasing with increased concentration of TPN. These properties may be the major reasons for the inhibition of lipid peroxidation. The results obtained in the present study indicate that the TPN has a potential source of natural antioxidant. In addition, analgesic effect of TPN was investigated in present study and TPN had strong analgesic effect. The analgesic effect of TPN compared with metamizol as a standard analgesic compound.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(03)00036-9