Oral subchronic toxicity of aqueous crude extract of Plantago australis leaves

The toxic effects of chronic oral administration (60 days) of aqueous crude extract (AE) of Plantago australis Lam. (Plantaginaceae) in rats at doses of 850 and 1700 mg/kg on biochemical (ALT, AST, creatinine, urea, glucose, alkaline phosphatase, total proteins and albumin), hematological (complete...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2003-09, Vol.88 (1), p.15-18
Main Authors: Palmeiro, N.M.S., Almeida, C.E., Ghedini, P.C., Goulart, L.S., Pereira, M.C.F., Huber, S., da Silva, J.E.P., Lopes, S.
Format: Article
Language:English
Subjects:
Administration, Oral
Alanine Transaminase - blood
Alanine Transaminase - drug effects
Animals
Biochemical
Biological and medical sciences
Blood - drug effects
Brazil
Complex Mixtures - administration & dosage
Complex Mixtures - toxicity
Female
General pharmacology
Hematological
Histopathological parameters
Lung - drug effects
Lung - pathology
Male
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - administration & dosage
Plant Extracts - toxicity
Plant Leaves - chemistry
Plant Leaves - toxicity
Plantago - chemistry
Plantago - toxicity
Plantago australis Lam
Rats
Rats, Wistar
Sex Factors
Subchronic toxicity
Toxicity Tests - methods
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Summary:The toxic effects of chronic oral administration (60 days) of aqueous crude extract (AE) of Plantago australis Lam. (Plantaginaceae) in rats at doses of 850 and 1700 mg/kg on biochemical (ALT, AST, creatinine, urea, glucose, alkaline phosphatase, total proteins and albumin), hematological (complete hemogram), and histopathological (heart, lung, liver, kidney, esophagus, stomach and gut) parameters were studied. All biochemical and hematological parameters were found to be in the normal range, but ALT in animals that received AE of 850 mg/kg was higher. Histopathological analysis of organs, especially the liver did not present alterations.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(03)00137-5