Evaluation of the hepatoprotective and antioxidant activity of Boehmeria nivea var. nivea and B. nivea var. tenacissima

In this study, the relationship between liver protective effects and antioxidant activity of Boehmeria nivea var. nivea (= B. nivea) and B. nivea var. tenacissima (= B. frutescens) was investigated. The water extracts of both plants exhibited a hepatoprotective activity against CCl 4-induced liver i...

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Bibliographic Details
Published in:Journal of ethnopharmacology 1998-02, Vol.60 (1), p.9-17
Main Authors: Lin, Chun-Ching, Yen, Ming-Hong, Lo, Tsae-shiuan, Lin, Jer-Min
Format: Article
Language:English
Subjects:
Animals
Antioxidants - pharmacology
Antioxidative
Ascorbic Acid - pharmacology
B. nivea var. tenacissima
Biological and medical sciences
Boehmeria nivea var. nivea
boehmeria nivea var. tenacissima
Carbon Tetrachloride - toxicity
Drug Evaluation
Electron spin resonance (ESR)
Electron Spin Resonance Spectroscopy
Ferrous Compounds - pharmacology
Free Radical Scavengers - pharmacology
General pharmacology
Hepatoprotective
Lipid Peroxidation
Liver - drug effects
Liver - enzymology
Liver - metabolism
Male
Medical sciences
medicinal plants
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Rats
Rats, Wistar
Superoxide Dismutase - metabolism
Superoxides - metabolism
traditional medicine
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Summary:In this study, the relationship between liver protective effects and antioxidant activity of Boehmeria nivea var. nivea (= B. nivea) and B. nivea var. tenacissima (= B. frutescens) was investigated. The water extracts of both plants exhibited a hepatoprotective activity against CCl 4-induced liver injury. B. nivea var. nivea and B. nivea var. tenacissima, also showed anti-oxidant effects in FeCl 2-ascorbate induced lipid peroxidation in rat liver homogenate. Moreover, the active oxygen species scavenging potencies were evaluated by an electron spin resonance (ESR) spin-trapping technique. B. nivea var. tenacissima displayed better superoxide radical scavenging activity than B. nivea. Based on these findings, we suggest that in the liver protective and antioxidative effects of B. nivea var. nivea and B. nivea var. tenacissima, possibly involve mechanisms related to free radical scavenging effects.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(97)00122-0