Studies on the anti-inflammatory and related pharmacological properties of the aqueous extract of Bridelia ferruginea stem bark

The anti-inflammatory profile of the aqueous extract of Bridelia ferruginea stem bark was investigated using both in vivo and in vitro models. The extract exhibited strong topical anti-inflammatory effect shown as inhibition of croton oil-induced ear oedema in mice, and reduced hind-paw swelling and...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2000-07, Vol.71 (1), p.153-160
Main Authors: Olajide, Olumayokun A, Makinde, J.Modupe, Okpako, David T, Awe, S.Olubusayo
Format: Article
Language:English
Subjects:
Acetic Acid
Analgesic
Animals
Anti-inflammatory
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Antineoplastic Agents, Alkylating
Antipyretic
Arthritis, Experimental - drug therapy
Biological and medical sciences
Bridelia ferruginea
Cyclophosphamide
Cystitis - chemically induced
Cystitis - prevention & control
Edema - chemically induced
Edema - prevention & control
Erythrocytes - drug effects
Euphorbiaceae - chemistry
Fever - chemically induced
Fever - prevention & control
General pharmacology
Hemorrhage - chemically induced
Hemorrhage - prevention & control
Humans
In Vitro Techniques
Male
Medical sciences
Membrane stabilization
Mice
Pain - chemically induced
Pain - prevention & control
Pain Measurement - drug effects
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plant Epidermis - chemistry
Plant Extracts - pharmacology
Plants, Medicinal - chemistry
Rats
Rats, Wistar
Topical inflammation
Vascular permeability
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Summary:The anti-inflammatory profile of the aqueous extract of Bridelia ferruginea stem bark was investigated using both in vivo and in vitro models. The extract exhibited strong topical anti-inflammatory effect shown as inhibition of croton oil-induced ear oedema in mice, and reduced hind-paw swelling and growth retardation in the adjuvant-induced arthritis model in rats, following oral administration at 10, 20, 40 or 80 mg/kg. The extract (10–80 mg/kg, p.o.) caused an inhibition of increase in vascular permeability in both cyclophosphamide-induced haemorrhagic cystitis and acetic acid-induced vascular permeability in rats and mice, respectively. B. ferruginea produced stabilization of erythrocytes exposed to heat and stress-induced lysis. Antipyretic and analgesic properties of the extract were also observed.
ISSN:0378-8741
1872-7573
DOI:10.1016/S0378-8741(99)00201-9