Evaluation of influenza A virus receptors

Sialic acid has long been considered the sole cellular receptor for influenza viruses, but it has been demonstrated that influenza can infect cells independently of surface sialic acid [Glycobiology 10 (2000) 649]. Here, we evaluate possible alternative influenza virus receptors, and find evidence f...

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Bibliographic Details
Published in:International Congress series 2001-10, Vol.1219, p.487-502
Main Authors: Stray, Stephen J, Air, Gillian M
Format: Article
Language:English
Subjects:
Influenza A virus receptor
Sialic acid
Terminal α− N-acetylgalactosamine
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Summary:Sialic acid has long been considered the sole cellular receptor for influenza viruses, but it has been demonstrated that influenza can infect cells independently of surface sialic acid [Glycobiology 10 (2000) 649]. Here, we evaluate possible alternative influenza virus receptors, and find evidence for specific virus-binding-proteins in vitro and mediation of entry by carbohydrates containing terminal α- N-acetylgalactosamine. Characterization of such receptors may lead to identification of alternative targets for the design of anti-influenza drugs.
ISSN:0531-5131
1873-6157
DOI:10.1016/S0531-5131(01)00639-2