Changes in the laryngeal signs of patients with reflux laryngitis: a prospective, placebo-controlled, randomized, double-blinded evaluation of omeprazole

Reflux laryngitis (RL) is becoming an increasingly reported clinical finding. Unfortunately, there are several problems associated with its diagnosis: total reliance on laryngeal symptoms leading to over-diagnosis, reliance on lower esophageal pH values for diagnosis leading to missed diagnosis, and...

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Bibliographic Details
Published in:International Congress series 2003-10, Vol.1240, p.843-851
Main Authors: Khidr, Aliaa, Noordzij, J.Pieter, Desper, Ellen, Meek, Robert, Reibel, James F, Levine, Paul A
Format: Article
Language:English
Subjects:
Laryngeal signs
Laryngo-pharyngeal reflux
Omeprazole
Reflux laryngitis
Reliability
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Summary:Reflux laryngitis (RL) is becoming an increasingly reported clinical finding. Unfortunately, there are several problems associated with its diagnosis: total reliance on laryngeal symptoms leading to over-diagnosis, reliance on lower esophageal pH values for diagnosis leading to missed diagnosis, and lack of consensus on how to evaluate and rate the most sensitive laryngeal signs leading to questionable diagnosis. These are further aggravated by the inherent research problems of outcome study designs. The current study has used positive laryngeal symptoms and positive laryngopharyngeal reflux (LPR) for diagnosis. Fifty-three subjects with positive persistent RL symptoms for 2 months were recruited. Only 30 had positive LPR (>4 episodes of pH
ISSN:0531-5131
1873-6157
DOI:10.1016/S0531-5131(03)00759-3