Improvement in solubility and dissolution rate of flavonoids by complexation with β-cyclodextrin

The inclusion into the β-cyclodextrin is used to improve pharmacokinetic characteristics of hesperetin and naringenin. Solubility of hesperetin and naringenin with increasing concentrations of β-cyclodextrin grows as long as the temperature increased. Stability constants were determined by the solub...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2004-04, Vol.35 (2), p.379-387
Main Authors: Tommasini, Silvana, Raneri, Daniela, Ficarra, Rita, Calabrò, Maria Luisa, Stancanelli, Rosanna, Ficarra, Paola
Format: Article
Language:English
Subjects:
Analysis
Analytical, structural and metabolic biochemistry
beta-Cyclodextrins - chemistry
beta-Cyclodextrins - metabolism
Biological and medical sciences
Dissolution
Flavonoids - chemistry
Flavonoids - metabolism
Fundamental and applied biological sciences. Psychology
General pharmacology
Hesperetin
Medical sciences
Naringenin
Pharmacology. Drug treatments
Phase solubility studies
Solubility
Solutions
β-Cyclodextrin
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Summary:The inclusion into the β-cyclodextrin is used to improve pharmacokinetic characteristics of hesperetin and naringenin. Solubility of hesperetin and naringenin with increasing concentrations of β-cyclodextrin grows as long as the temperature increased. Stability constants were determined by the solubility method by Higuchi and Connors at different temperatures, and the thermodynamic parameters were calculated for inclusion complex formation in aqueous solution. The solid complexes were obtained in a molar ratio of 1:1 and their dissolution behavior at different pH was examined.
ISSN:0731-7085
1873-264X
DOI:10.1016/S0731-7085(03)00647-2