Multicenter Evaluation of the In Vitro Activity of Six Broad-Spectrum β-Lactam Antimicrobial Agents in Puerto Rico

The minimum inhibitory concentrations of 6 broad-spectrum β-lactam antimicrobial agents were determined by use of the Etest versus a total of 569 bacteria in 7 Puerto Rican hospital laboratories. These included 342 recent clinical isolates of Enterobacteriaceae, 63 Pseudomonas aeruginosa, 54 Acineto...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 1998-02, Vol.30 (2), p.113-119
Main Authors: Group, Doern, Gary V, Jones, Ronald N, Pfaller, Michael A, Erwin, Meridith, Ramirez-Rhonda, Carlos
Format: Article
Language:English
Subjects:
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Biological and medical sciences
Medical sciences
Pharmacology. Drug treatments
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Summary:The minimum inhibitory concentrations of 6 broad-spectrum β-lactam antimicrobial agents were determined by use of the Etest versus a total of 569 bacteria in 7 Puerto Rican hospital laboratories. These included 342 recent clinical isolates of Enterobacteriaceae, 63 Pseudomonas aeruginosa, 54 Acinetobacter species, and 110 oxacillin-susceptible staphylococci. Extended spectrum β-lactamase production was noted among 11% of Klebsiella pneumoniae isolates. Hyperproduction of Amp C cephalosporinase was observed with >20% of isolates of Enterobacter spp., Serratia spp., and Citrobacter freundii. The overall rank order of activity of the six β-lactams examined in this study versus all clinical isolates was imipenem (95.8% susceptible) > cefepime (91.1%) > piperacillin/ tazobactam (82.3%) > cefotaxime (77.6%) > piperacillin (72.5%) > ceftazidime (67.0%).
ISSN:0732-8893
1879-0070
DOI:10.1016/S0732-8893(97)00160-0