Relation of alcohol intake to left ventricular mass: The Framingham study

Alcohol has direct toxic effects on the myocardium and is associated with elevated blood pressure, but its relation to left ventricular mass independent of blood pressure level has not been assessed. Reported alcohol intake and left ventricular mass measured by echocardiography were evaluated in 1,9...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 1991-03, Vol.17 (3), p.717-721
Main Authors: Manolio, Teri A., Levy, Daniel, Garrison, Robert J., Castelli, William P., Kannel, William B.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Aging - pathology
Alcohol Drinking - adverse effects
Alcoholism and acute alcohol poisoning
Biological and medical sciences
Cardiomegaly - etiology
Cardiomegaly - pathology
Echocardiography
Female
Heart - drug effects
Humans
Male
Medical sciences
Middle Aged
Stroke Volume - physiology
Toxicology
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Summary:Alcohol has direct toxic effects on the myocardium and is associated with elevated blood pressure, but its relation to left ventricular mass independent of blood pressure level has not been assessed. Reported alcohol intake and left ventricular mass measured by echocardiography were evaluated in 1,980 men and 2,511 women 17 to 90 years of age and free of cardiovascular disease in the Framingham offspring and cohort study. The relation of reported alcohol intake to left ventricular mass was assessed by gender-specific multivariate regression analysis adjusting for age, height, body mass index, systolic blood pressure, history of hypertension and cigarette smoking. Alcohol intake was positively associated with left ventricular mass in men (p < 0.01) but not in women (p = 0.64). When stratified by beverage type, beer and wine in both men and women and liquor in men were positively related to left ventricular mass. The lack of association of total alcohol intake to left ventricular mass in women appeared to be due to a negative association (p < 0.01) with liquor. The strongest positive associations were with wine in men (p < 0.001) and beer in women (p < 0.05). Alcohol use is independently associated with left ventricular mass; this association may vary by beverage type. In persons with unexplained left ventricular hypertrophy, excessive alcohol intake should be considered.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(10)80189-5