A prospective randomized trial of prevention measures in patients at high risk for contrast nephropathy

Objectives This study was done to test the hypothesis that a forced diuresis with maintenance of intravascular volume after contrast exposure would reduce the rate of contrast-induced renal injury. Background We have previously shown a graded relationship with the degree of postprocedure renal failu...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 1999-02, Vol.33 (2), p.403-411
Main Authors: Stevens, Melissa A., McCullough, Peter A., Tobin, Kenneth J., Speck, John P., Westveer, Douglas C., Guido-Allen, Debra A., Timmis, Gerald C., O’Neill, William W.
Format: Article
Language:English
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Summary:Objectives This study was done to test the hypothesis that a forced diuresis with maintenance of intravascular volume after contrast exposure would reduce the rate of contrast-induced renal injury. Background We have previously shown a graded relationship with the degree of postprocedure renal failure and the probability of in-hospital death in patients undergoing percutaneous coronary intervention. Earlier studies of singular prevention strategies (atrial natriuretic factor, loop diuretics, dopamine, mannitol) have shown no clear benefit across a spectrum of patients at risk. Methods A prospective, randomized, controlled, single-blind trial was conducted where 98 participants were randomized to forced diuresis with intravenous crystalloid, furosemide, mannitol (if pulmonary capillary wedge pressure
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(98)00574-9