Ondansetron in Nausea and Vomiting Induced by Spinal Morphine

Nausea and vomiting induced by opioids are relatively frequent in advanced cancer patients, although other factors may play a role. These effects, which tend to disappear after repeated dosing, can usually be controlled with antiemetic drugs, including metoclopramide, haloperidol, and phenothiazines...

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Bibliographic Details
Published in:Journal of pain and symptom management 1998-10, Vol.16 (4), p.259-262
Main Authors: Mercadante, Sebastiano, Sapio, Monica, Serretta, Roberto
Format: Article
Language:English
Subjects:
Analgesics, Opioid - adverse effects
Antiemetics - therapeutic use
Biological and medical sciences
Drug toxicity and drugs side effects treatment
Female
Humans
Injections, Spinal
Medical sciences
Middle Aged
Morphine - adverse effects
Nausea - drug therapy
Nausea and vomiting
ondansetron
Ondansetron - therapeutic use
opioids
palliative care
Palliative Care - methods
Pharmacology. Drug treatments
Toxicity: digestive system
Vomiting - drug therapy
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Summary:Nausea and vomiting induced by opioids are relatively frequent in advanced cancer patients, although other factors may play a role. These effects, which tend to disappear after repeated dosing, can usually be controlled with antiemetic drugs, including metoclopramide, haloperidol, and phenothiazines. Occasionally, nausea and vomiting persist, in spite of the prolonged administration of the antiemetic treatment. We report a patient who had nausea and vomiting that was resistant to common antiemetic treatments, change in opioid drugs, and change in route of administration, and who had a complete and immediate response to parenteral or oral ondansetron.
ISSN:0885-3924
1873-6513
DOI:10.1016/S0885-3924(98)00082-7