Use and monitoring of bromides in epilepsy treatment

Bromides are no longer a mainstay of epilepsy therapy because of the significant toxicity associated with their use and the availability of safer agents. However, bromides occasionally find a niche in the treatment of patients with refractory seizures, particularly in pediatrics. When the decision t...

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Bibliographic Details
Published in:Pediatric Neurology 1999-08, Vol.21 (2), p.523-528
Main Authors: Ryan, Melody, Baumann, Robert J
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Bromides - adverse effects
Bromides - pharmacokinetics
Bromides - therapeutic use
Drug Interactions
Epilepsy - drug therapy
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Humans
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Neuropharmacology
Pharmacology. Drug treatments
Pregnancy
Pregnancy Complications - drug therapy
Rats
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Summary:Bromides are no longer a mainstay of epilepsy therapy because of the significant toxicity associated with their use and the availability of safer agents. However, bromides occasionally find a niche in the treatment of patients with refractory seizures, particularly in pediatrics. When the decision to utilize this therapy is made, the clinician may be frustrated by the lack of concise, current information regarding bromides. This review provides an update on the mechanism of action, efficacy, pharmacokinetics, dose, and adverse effects of bromides.
ISSN:0887-8994
1873-5150
DOI:10.1016/S0887-8994(99)00021-1