The oxidative modification hypothesis of atherogenesis: an overview

The literature relating lipid and lipoprotein oxidation to atherosclerosis has expanded enormously in recent years. Papers on the “oxidative modification hypothesis” of atherogenesis have ranged from the most basic studies of the chemistry and enzymology of LDL oxidation, through studies of the biol...

Full description

Saved in:
Bibliographic Details
Published in:Free radical biology & medicine 2000-06, Vol.28 (12), p.1815-1826
Main Authors: Chisolm, Guy M, Steinberg, Daniel
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Antioxidants - metabolism
Antioxidants - pharmacology
Arteriosclerosis - etiology
Arteriosclerosis - metabolism
Arteriosclerosis - prevention & control
Atherosclerosis
Disease Models, Animal
Disease Progression
Enzymes - metabolism
Foam Cells - metabolism
Free radicals
Humans
Ligands
Lipoproteins, LDL - biosynthesis
Lipoproteins, LDL - metabolism
Macrophages - metabolism
Mice
Mice, Knockout
Mice, Transgenic
Oxidation-Reduction
Oxidized LDL
Proteins - metabolism
Receptors, Cell Surface - metabolism
Scavenger receptors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The literature relating lipid and lipoprotein oxidation to atherosclerosis has expanded enormously in recent years. Papers on the “oxidative modification hypothesis” of atherogenesis have ranged from the most basic studies of the chemistry and enzymology of LDL oxidation, through studies of the biological effects of oxidized LDL on cultured cells, and on to in vivo studies of the effects of antioxidants on atherosclerosis in animals and humans. The data in support of this theory are mounting but many key questions remain unanswered. For example, while it is generally agreed that LDL undergoes oxidation and that oxidized LDL is present in arterial lesions, it is still not known how and where LDL gets oxidized in vivo nor which of its many biological effects demonstrable in vitro are relevant to atherogenesis in vivo. This brief review is not intended to be comprehensive but rather to offer a perspective and a context for this Forum. We discuss the strengths and weaknesses of each line of evidence, try to identify areas in which further research is needed, assess the relevance of the hypothesis to the human disease, and point to some of the potential targets for therapy.
ISSN:0891-5849
1873-4596
DOI:10.1016/S0891-5849(00)00344-0