The glycine allele of a glycine/arginine polymorphism in the β2-adrenergic receptor gene is associated with essential hypertension in a population of Chinese origin

• Published in: American journal of hypertension 2001-12, Vol.14 (12), p.1196-1200
• Main Authors: Ranade, Koustubh, Shue, Wayne H-H., Hung, Yi-Jen, Hsuing, Chao A., Chiang, Fu-Tein, Pesich, Robert, Hebert, Joan, Olivier, Michael, Chen, Yii-Der I., Pratt, Richard, Olshen, Richard, Curb, David, Botstein, David, Risch, Neil, Cox, David R.
• Format: Article
• Language: English
• Subjects: Arterial hypertension. Arterial hypotension; association; Biological and medical sciences; Blood and lymphatic vessels; blood pressure variation; Cardiology. Vascular system; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Hypertension; Medical sciences; polymorphism; β2-adrenergic receptor
• ISSN: 0895-7061; 1941-7225; 1879-1905
• DOI: 10.1016/S0895-7061(01)02213-0

Background: Several studies implicate polymorphisms in the human β2-adrenergic receptor gene (ADRB2) in the susceptibility to hypertension. We sought to replicate these results in a population of Chinese origin primarily from Taiwan and the San Francisco Bay area. Methods: We genotyped >800 hypertensive subjects and individuals with low-normal blood pressure that were derived largely from the same families as the hypertensive patients for three polymorphisms in the ADRB2 gene: a C/T transition at position 47 (C-47T) in the 5′ leader cistron; another C/T transition that results in a glycine/arginine substitution at codon 16 (Gly16Arg), and a G/C transversion that causes a glutamate/glutamine substitution at codon 27 (Glu27Gln). Results: The Gly16Arg was significantly associated with hypertension (P < .03). Under a dominant model, for hypertension the relative risk for the Gly/Gly and Gly/Arg genotypes versus the Arg/Arg genotype was 1.35 (95% confidence limits [CL] 1.08, 1.70); for low-normal blood pressure the relative risk was 0.79 (95% CL 0.66, 0.94). This polymorphism explained approximately 1% of the variance in systolic and diastolic blood pressures in our study population. There was no evidence of association between the C-47T and Glu27Gln polymorphisms and hypertension in this population. Conclusions: The Gly16 allele in the β2-adrenergic receptor gene is a susceptibility allele for essential hypertension in a population of Chinese origin. Am J Hypertens 2001;14:1196–1200 © 2001 American Journal of Hypertension, Ltd.