Proconvulsant effect of aminophylline on cortical epileptic afterdischarges varies during ontogeny

• Published in: Epilepsy research 2000-05, Vol.39 (3), p.183-190
• Main Authors: BERNASKOVA, K, MARES, P
• Format: Article
• Language: English
• Subjects: Aminophylline - toxicity; Animals; Behavior, Animal - drug effects; Behavior, Animal - physiology; Biological and medical sciences; Bronchodilator Agents - toxicity; Cerebral cortex; Cerebral Cortex - drug effects; Cerebral Cortex - embryology; Cerebral Cortex - physiopathology; Convulsants - toxicity; Development; Drug toxicity and drugs side effects treatment; Electric Stimulation; Electrodes, Implanted; Electroencephalography - drug effects; Epilepsy - chemically induced; Epilepsy - physiopathology; Epileptic afterdischarges; Female; Medical sciences; Motor Cortex - drug effects; Motor Cortex - embryology; Motor Cortex - physiopathology; Movement - physiology; Pharmacology. Drug treatments; Pregnancy; Rat; Rats; Rats, Wistar; Somatosensory Cortex - drug effects; Somatosensory Cortex - embryology; Somatosensory Cortex - physiopathology; Theophylline; Toxicity: nervous system and muscle
• ISSN: 0920-1211; 1872-6844
• DOI: 10.1016/S0920-1211(99)00118-7

Effect of aminophylline on epileptic afterdischarges (ADs) induced repeatedly by rhythmic electrical stimulation of sensorimotor cortical area was studied in rat pups 12, 18 and 25 days old. The proconvulsant effect of aminophylline (50 and/or 100 mg/kg i.p.) was more expressed in 12- and 18-day-old rats than in the oldest group. In 12-day-old rat pups there was an enormous increase of transition of the spike-and-wave type of ADs into the second, limbic type, a situation observed only exceptionally under control conditions. A prolongation of ADs was related to this transition (limbic ADs are always longer than spike-and-wave ones). Eighteen-day-old rats exhibit this transition less frequently but a marked prolongation of spike-and-wave ADs was recorded in a part of these animals forming a pattern of status lasting some tens of minutes. Aminophylline led only to a transient prolongation of spike-and-wave ADs in the oldest group. The transition into the limbic type of ADs was seen in this age group only exceptionally what is in contrast to age-matched controls in which this transition is common. The effect of aminophylline on cortical ADs which is most marked in the youngest group changes qualitatively during postnatal development.