Estrogen-induced tumorigenesis in the pituitary gland of TGF-β(+/−) knockout mice

Transforming growth factor (TGF)-β receptor type II gene ( Tgfbr2) knockout and wild type mice underwent chronic estrogen exposure using estradiol pellets. Histological examination of the pituitary glands found 38 adenomas in 14 Tgfbr2(+/−) mice but only one tumor in ten wild type mice. Pituitary tu...

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Bibliographic Details
Published in:Biochimica et biophysica acta 1998-07, Vol.1407 (1), p.79-83
Main Authors: Shida, Naoki, Ikeda, Hidetoshi, Yoshimoto, Takashi, Oshima, Masanobu, Taketo, Makoto M., Miyoshi, Ichiro
Format: Article
Language:English
Subjects:
Adenoma - chemically induced
Adenoma - pathology
Animals
C57BL/6J mouse
Estradiol - pharmacology
Estrogen
Heterozygote
Knockout mouse
Mice
Mice, Knockout
Pituitary adenoma
Pituitary Neoplasms - chemically induced
Pituitary Neoplasms - pathology
Protein-Serine-Threonine Kinases
Receptor, Transforming Growth Factor-beta Type II
Receptors, Transforming Growth Factor beta - analysis
Receptors, Transforming Growth Factor beta - genetics
Transforming growth factor-β
Transforming growth factor-β receptor type II
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Summary:Transforming growth factor (TGF)-β receptor type II gene ( Tgfbr2) knockout and wild type mice underwent chronic estrogen exposure using estradiol pellets. Histological examination of the pituitary glands found 38 adenomas in 14 Tgfbr2(+/−) mice but only one tumor in ten wild type mice. Pituitary tumorigenesis is greatly accelerated in Tgfbr2(+/−) mice by estrogen treatment.
ISSN:0925-4439
0006-3002
1879-260X
DOI:10.1016/S0925-4439(98)00024-6