The mouse deafness locus ( dn) is associated with an inversion on chromosome 19

Recombination data for the mouse deafness locus ( dn) on chromosome 19 are consistent with the presence of an inversion for which one of the breakpoints is between D19Mit14 and D19Mit96, a distance of less than 226 kb. Fluorescence in situ hybridization studies using a bacterial artificial chromosom...

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Bibliographic Details
Published in:Biochimica et biophysica acta 1998-09, Vol.1407 (3), p.257-262
Main Authors: Viñas, Ana M, Drury, Stacy S, DeAngelis, Margaret M, Den, Zhining, Huang, Jer-Min, Berlin, Charles I, Hunt, Jay D, Batzer, Mark A, Deininger, Prescott L, Keats, Bronya J.B
Format: Article
Language:English
Subjects:
Animals
Chromosome 19
Chromosome Inversion
Deafness
Deafness - genetics
Fluorescein-5-isothiocyanate
Genes
Genotype
In Situ Hybridization, Fluorescence
Inbreeding
Inversion
Mice
Mouse
Non-syndromic hearing impairment
Polymerase Chain Reaction
Rhodamines
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Summary:Recombination data for the mouse deafness locus ( dn) on chromosome 19 are consistent with the presence of an inversion for which one of the breakpoints is between D19Mit14 and D19Mit96, a distance of less than 226 kb. Fluorescence in situ hybridization studies using a bacterial artificial chromosome on interphase (G 1) nuclei provide additional support for the presence of an inversion. The dn gene is probably the orthologue of the human DFNB7/DFNB11 gene on chromosome 9.
ISSN:0925-4439
0006-3002
1879-260X
DOI:10.1016/S0925-4439(98)00050-7