Toxic epidermal necrolysis following morbilli-parotitis-rubella vaccination

• Published in: Journal of the European Academy of Dermatology and Venereology 1999-07, Vol.13 (1), p.59-61
• Main Authors: Dobrosavljevic, Danijela, Milinkovic, Mirjana V, Nikolic, Milos M
• Format: Article
• Language: English
• Subjects: Adolescent; Anti-Bacterial Agents; Drug Therapy, Combination - therapeutic use; Female; Follow-Up Studies; Humans; Measles Vaccine - adverse effects; Measles-Mumps-Rubella Vaccine; Morbilli-parotitis-rubella vaccine; Mumps Vaccine - adverse effects; Rubella Vaccine - adverse effects; Stevens-Johnson Syndrome - diagnosis; Stevens-Johnson Syndrome - drug therapy; Stevens-Johnson Syndrome - etiology; Toxic epidermal necrolysis; Vaccination; Vaccines, Combined - adverse effects
• ISSN: 0926-9959; 1468-3083
• DOI: 10.1016/S0926-9959(99)00065-3

We present the first reported case of toxic epidermal necrolysis (TEN) caused by morbilli-parotitis-rubella (MPR) vaccine. A 13-year-old girl developed TEN 7 days after she received live, attenuated, triple MPR vaccine. The history of drug intake and any illness was negative. At admission the patient was acutely ill with high fever. The whole body was erythematous. The epidermis was wrinkled and the Nikolsky sign was positive. Numerous erosions were present on the lips and genital region. On the seventh day of illness, the eruption involved 80% of the skin. Systemic corticosteroid therapy was not employed. The skin and mucosal defects completely epithelized by the end of the third week of illness. Mild keratoconjunctivitis sicca remained because of permanent cup cell damage.