Surface modification of segmented poly(ether urethane) by grafting sulfo ammonium zwitterionic monomer to improve hemocompatibilities

Segmented poly(ether urethane) (SPEU) was synthesized from 4,4′-diphenylmethane-diisocyanate, polytetramethylene glycol and 1,4-butandiol. SPEU was hydroxylated by potassium peroxosulfate and N, N-dimethyl- N-methacryloxyethyl- N-(3-sulfopropyl) ammonium was grafted onto hydroxylated SPEU using ceri...

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2003-04, Vol.28 (1), p.1-9
Main Authors: Jun, Zhang, Youling, Yuan, Kehua, Wu, Jian, Shen, Sicong, Lin
Format: Article
Language:English
Subjects:
Ceric ammonium nitrate
DMMSA
Graft copolymerizaiton
Hydroxylation
Poly(ether urethane)
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Summary:Segmented poly(ether urethane) (SPEU) was synthesized from 4,4′-diphenylmethane-diisocyanate, polytetramethylene glycol and 1,4-butandiol. SPEU was hydroxylated by potassium peroxosulfate and N, N-dimethyl- N-methacryloxyethyl- N-(3-sulfopropyl) ammonium was grafted onto hydroxylated SPEU using ceric ammonium nitrate as initiator. The bulk characterization of synthesized SPEU was investigated by FTIR and equilibrium water content. Surface analysis of grafted SPEU film was studied by ATR-FTIR, electron spectroscopy for chemical analysis and contact angle measurements, which confirmed graft copolymerization. Blood compatibility of grafted SPEU films was evaluated by platelet adhesion and whole blood contacting experiments using SPEU film as the control. Grafted SPEU does appear to possess good antithrombogenic properties. This new sulfo ammonium zwitterionic structure molecules grafted biomaterials may have potential for biomedical applications.
ISSN:0927-7765
1873-4367
DOI:10.1016/S0927-7765(02)00116-9