Various ulcerogenic stimuli are potentiated by glucocorticoid deficiency in rats

The effects of glucocorticoid deficiency with or without corticosterone replacement on susceptibility to gastric mucosal injury by various ulcerogenic stimuli have been evaluated in rats. Gastric erosions were induced in male rats by stimuli of different modalities and intensities: 20% ethanol (po),...

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Bibliographic Details
Published in:Journal of physiology, Paris Paris, 2001, Vol.95 (1), p.59-65
Main Authors: Filaretova, Ludmila, Bagaeva, Tatiana, Podvigina, Tatiana, Makara, Gabor
Format: Article
Language:English
Subjects:
Acetic Acid
Adrenalectomy
Animals
Aspirin
Corticosterone - blood
Corticosterone - pharmacology
Ethanol
Gastric erosions
Gastric Mucosa - drug effects
Gastric Mucosa - pathology
Glucocorticoid deficiency
Glucocorticoids - antagonists & inhibitors
Glucocorticoids - deficiency
Hydrocortisone - pharmacology
Male
Rats
Rats, Sprague-Dawley
Stomach Ulcer - chemically induced
Stomach Ulcer - pathology
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Summary:The effects of glucocorticoid deficiency with or without corticosterone replacement on susceptibility to gastric mucosal injury by various ulcerogenic stimuli have been evaluated in rats. Gastric erosions were induced in male rats by stimuli of different modalities and intensities: 20% ethanol (po), aspirin (300 mg/kg, ip), acidified aspirin (40 mM, po) and 100% acetic acid (applied to gastric serosa). Glucocorticoid supply was decreased by adrenalectomy or by delayed inhibitory action after a single pharmacological dose of cortisol (300 mg/kg, ip) injected one week before the onset of ulcerogenic stimulus. Corticosterone for replacement (4 mg/kg, sc) was injected in rats with glucocorticoid deficiency 15 min before the onset of ulcerogenic stimulus. Plasma corticosterone levels were measured by fluorometry. Gastric erosions were quantitated by measuring the area of damage. Ulcerogenic stimuli induced both plasma corticosterone rise and gastric mucosal injury. The area of mucosal damages induced various stimuli ranged from small to extensive. Glucocorticoid deficiency significantly potentiated an ulcerogenic action of every ulcerogenic stimulus. Replacing corticosterone prevented or significantly decreased erosion-potentiating effect of glucocorticoid deficiency. These results show that endogenous glucocorticoids released during ulcerogenic influences help gastric mucosa to resist a harmful action of both weak and strong ulcerogenic stimuli.
ISSN:0928-4257
1769-7115
DOI:10.1016/S0928-4257(01)00069-9