Cisplatin and acute tubular necrosis

We report an unusually short lived and asymptomatic episode of severe cisplatin-induced renal tubular salt wasting in a fit 41-year-old patient with malignant teratoma. This was associated with polyuria but no significant hyponatraemia. Full recovery occurred because of early pick up, emhasizing the...

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Bibliographic Details
Published in:Clinical oncology (Royal College of Radiologists (Great Britain)) 1997, Vol.9 (4), p.267-268
Main Authors: Wadd, N.J., Tiplady, C., Roberts, J.T.
Format: Article
Language:English
Subjects:
Acute tubular necrosis
Adult
Antineoplastic Agents - adverse effects
Biological and medical sciences
Cisplatin
Cisplatin - adverse effects
Drug toxicity and drugs side effects treatment
Humans
Kidney Tubular Necrosis, Acute - chemically induced
Kidney Tubular Necrosis, Acute - diagnosis
Male
Malignant teratoma
Medical sciences
Pharmacology. Drug treatments
Salt-losing neuropathy
Teratoma - drug therapy
Testicular Neoplasms - drug therapy
Toxicity: urogenital system
Citations: Items that this one cites
Online Access:Get full text
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Summary:We report an unusually short lived and asymptomatic episode of severe cisplatin-induced renal tubular salt wasting in a fit 41-year-old patient with malignant teratoma. This was associated with polyuria but no significant hyponatraemia. Full recovery occurred because of early pick up, emhasizing the need for careful fluid balance monitoring of patients receiving cisplatin chemotherapy.
ISSN:0936-6555
1433-2981
DOI:10.1016/S0936-6555(97)80016-7