Melatonin and colon carcinogenesis

Forty-eight two-month-old outbred female LIO rats were injected weekly with a single dose of 1,2-dimethylhydrazine (DMH; 21 mg/kg of body weight) administered s.c. for 15 consecutive weeks. From the day of the 1st injection of the carcinogen the part of rats were given five days a week during the ni...

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Bibliographic Details
Published in:Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2000-03, Vol.52 (1), p.71-76
Main Authors: Anisimov, V.N., Popovich, I.G., Shtylik, A.V., Zabezhinski, M.A., Ben-Huh, H., Gurevich, P., Berman, V., Tendler, Y., Zusman, I.
Format: Article
Language:English
Subjects:
1,2-dimethylhydrazine
Apoptosis
Carcinogenesis
colon
Colon carcinogenesis
Melatonin
Proliferative activity
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Summary:Forty-eight two-month-old outbred female LIO rats were injected weekly with a single dose of 1,2-dimethylhydrazine (DMH; 21 mg/kg of body weight) administered s.c. for 15 consecutive weeks. From the day of the 1st injection of the carcinogen the part of rats were given five days a week during the night time (from 18.00 h to 08.00 h) melatonin dissolved in tap water, 20 mg/l. 10 rats were treated similaly with solvents and served as control. The experiment was terminated 6 months after the first injection of the carcinogen. Colon tumors (mainly adenocarcinomas) developed in a hundred percent of rats exposed both to DMH or to DMH plus melatonin. However, descending colon carcinomas were observed in 65% of rats exposed to DMH plus melatonin against 100% in those exposed to DMH alone (p
ISSN:0940-2993
1618-1433
DOI:10.1016/S0940-2993(00)80022-6