Muscarinic receptors and insulin concentration in the rat pancreas after chronic alcohol intake and cholinergic stimulation

The effects of chronic alcohol intake and carbachol stimulation on pancreatic muscarinic receptor binding and insulin concentrations were studied in the rat pancreas. There was a strong correlation between the number of muscarinic receptors and the concentration of insulin in the pancreas. The conce...

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Bibliographic Details
Published in:Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 1996, Vol.48 (1), p.77-79
Main Authors: Laine, V.J.O., Huupponen, R., Kaila, T., Grönroos, J., Nevalainen, T.J.
Format: Article
Language:English
Subjects:
Alcohol, chronic intake
Alcoholism and acute alcohol poisoning
Animals
Biological and medical sciences
Carbachol
Carbachol - pharmacology
Dose-Response Relationship, Drug
Ethanol - administration & dosage
Ethanol - metabolism
Ethanol - toxicity
Ethanol, chronic intake
Insulin
Insulin - metabolism
Male
Medical sciences
Muscarinic receptors
N-Methylscopolamine
Pancreas
Pancreas - drug effects
Pancreas - metabolism
Radioligand Assay
Rats
Rats, Sprague-Dawley
Receptors, Muscarinic - chemistry
Receptors, Muscarinic - drug effects
Scopolamine Derivatives - analysis
Toxicology
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Summary:The effects of chronic alcohol intake and carbachol stimulation on pancreatic muscarinic receptor binding and insulin concentrations were studied in the rat pancreas. There was a strong correlation between the number of muscarinic receptors and the concentration of insulin in the pancreas. The concentration of insulin decreased in the pancreas after long-term ethanol exposure and increased after carbachol stimulation. These results indicate that the secretion of insulin is mediated via the muscarinic receptor pathway, and that the changes in the number of muscarinic receptors may have a role in insulin deficiency after long-term alcohol consumption.
ISSN:0940-2993
1618-1433
DOI:10.1016/S0940-2993(96)80096-0