Identification of components of Prunus africana extract that inhibit lipid peroxidation

Extractive and chromatographic separations were performed on V-1326, a chloroform extract from the bark of Prunus africana (also referred to as Pygeum africanum), which is used to treat the symptoms associated with benign prostate hyperplasia (BPH). The relative amounts of eleven identified constitu...

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Bibliographic Details
Published in:Phytomedicine (Stuttgart) 1999-11, Vol.6 (5), p.379-388
Main Authors: Hass, Martha A., Nowak, Deanne M., Leonova, Elena, Levin, Robert M., Longhurst, Penelope A.
Format: Article
Language:English
Subjects:
benign prostate hyperplasia
Biological Assay
Chromatography, Gas
Inhibitory Concentration 50
lipid peroxidation
Lipid Peroxidation - drug effects
Myristic Acid
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Prunus - chemistry
Prunus africana
Pygeum africanum
Tadenan
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Summary:Extractive and chromatographic separations were performed on V-1326, a chloroform extract from the bark of Prunus africana (also referred to as Pygeum africanum), which is used to treat the symptoms associated with benign prostate hyperplasia (BPH). The relative amounts of eleven identified constituents in crude V-1326 and in separated fractions were determined using gas chromatographic analysis. The ability of V-1326 and its separated fractions to inhibit ferrous ion-induced stimulation of lipid peroxidation in microsomal preparations from rabbit livers was evaluated. The extract, V-1326, and fractions containing high levels of myristic acid potently inhibited lipid peroxidation.
ISSN:0944-7113
1618-095X
DOI:10.1016/S0944-7113(99)80063-4