Postoperative nausea and vomiting after total intravenous anesthesia with propofol and remifentanil or alfentanil: how important is the opioid?

• Published in: Journal of clinical anesthesia 2002-06, Vol.14 (4), p.275-278
• Main Authors: Dershwitz, Mark, Michałowski, Piotr, Chang, YuChiao, Rosow, Carl E, Conlay, Lydia A
• Format: Article
• Language: English
• Subjects: Adult; Alfentanil; Alfentanil - administration & dosage; Alfentanil - adverse effects; Analgesics; Analgesics, Opioid - administration & dosage; Analgesics, Opioid - adverse effects; Anesthesia; Anesthesia depending on type of surgery; Anesthesia, General; Anesthesia, Intravenous; anesthesia, total intravenous; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anesthetics, Combined; Anesthetics, Intravenous - administration & dosage; Arthroscopy; Biological and medical sciences; Double-Blind Method; emesis; Female; Humans; Knee Joint - surgery; Male; Medical sciences; nausea and vomiting, postoperative; Neuropharmacology; Orthopedic surgery. Maxillofacial surgery. Otorhinolaryngologic surgery. Stomatology. Ophtalmology. Investigation and treatment technics; outpatient surgery; Pharmacology. Drug treatments; Piperidines - administration & dosage; Piperidines - adverse effects; Postoperative Nausea and Vomiting - chemically induced; Postoperative Nausea and Vomiting - therapy; Propofol - administration & dosage; remifentanil; Shoulder Joint - surgery
• ISSN: 0952-8180; 1873-4529
• DOI: 10.1016/S0952-8180(02)00353-7

Study Objective: To compare the frequency and duration of postoperative nausea and vomiting (PONV) following total intravenous anesthesia (TIVA) with propofol and either remifentanil or alfentanil in outpatients undergoing arthroscopic surgery of the extremities. Design: Randomized, third-party blinded study. Setting: University medical center. Patients: 100 ASA physical status I and II patients scheduled for arthroscopic surgery of the knee or shoulder. Interventions: The anesthesia regimen consisted of a bolus followed by continuous infusion of propofol (2 mg/kg followed by 120μ g/kg/min) and the opioid (remifentanil 0.5 μ g/kg followed by 0.1 μ g/kg/min or alfentanil 10 μ g/kg followed by 0.25 μ g/kg/min). Patients breathed 100% oxygen spontaneously through a Laryngeal Mask Airway™ (or an endotracheal tube when medically indicated). Opioids were titrated to maintain blood pressure and heart rate within 20% of baseline and a respiratory rate of 10 to 16 breaths/min. Propofol was titrated downward as low as possible without permitting patient movement. Measurements: Nausea was determined by an 11-point categorical scale and was recorded before surgery and multiple time points thereafter. The times of emetic episodes were recorded. Treatment of PONV was at the discretion of the postanesthesia care unit (PACU) nurses who were blinded to the identity of the opioid used. Main Results: Nausea scores were 0 at all time points in over 70% of the patients in each group. None of the 100 patients vomited while in the hospital, and only one patient required antiemetic therapy. Conclusion: When propofol-based TIVA is used for arthroscopic surgery, short-acting opioids do not significantly affect the risk of PONV.