Novel tocotrienols of rice bran modulate cardiovascular disease risk parameters of hypercholesterolemic humans

Tocotrienols inhibit cholesterol synthesis by post-transcriptionally suppressing β-hydroxy-β-methylglutaryl-coenzyme A reductase activity. A double blind, 12-week study was performed to investigate the effect of a novel tocotrienol-rich fraction (TRF 25; obtained by molecular distillation from speci...

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Bibliographic Details
Published in:The Journal of nutritional biochemistry 1997-05, Vol.8 (5), p.290-298
Main Authors: Qureshi, Asaf A., Bradlow, Basil A., Salser, Winston A., Brace, Larry D.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiology. Vascular system
Cardiopathies: etiologic forms (general aspects and miscellaneous)
Heart
Medical sciences
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Summary:Tocotrienols inhibit cholesterol synthesis by post-transcriptionally suppressing β-hydroxy-β-methylglutaryl-coenzyme A reductase activity. A double blind, 12-week study was performed to investigate the effect of a novel tocotrienol-rich fraction (TRF 25; obtained by molecular distillation from specially processed rice bran oil) on cardiovascular disease risk factors of hypercholesterolemic human subjects (serum total cholesterol >5.69 mmol/L). After acclimation to an alcohol-free regimen (baseline) participants were assigned to the National Cholesterol Education Program (NCEP) Step-1 diet (saturated fat
ISSN:0955-2863
1873-4847
DOI:10.1016/S0955-2863(97)89667-2