Preparation of a new FerroPHOS derivative for palladium-catalyzed asymmetric allylic alkylations

A new C 2-symmetric only cylindrically chiral FerroPHOS derivative possessing (1-methoxy-1-methyl)ethyl substituents was prepared and applied to the palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenylprop-2-en-1-yl acetate. Both high catalytic activity (up to 500 turnovers) and enantio...

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Bibliographic Details
Published in:Tetrahedron: asymmetry 2001-02, Vol.12 (1), p.33-35
Main Authors: Kang, Jahyo, Lee, Jun Hee, Choi, Jung Sun
Format: Article
Language:English
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Summary:A new C 2-symmetric only cylindrically chiral FerroPHOS derivative possessing (1-methoxy-1-methyl)ethyl substituents was prepared and applied to the palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenylprop-2-en-1-yl acetate. Both high catalytic activity (up to 500 turnovers) and enantioselectivity (e.e.'s of up to 96.3%) were attained in reactions using the new diphosphine ligand. Graphic
ISSN:0957-4166
1362-511X
DOI:10.1016/S0957-4166(01)00019-2