An enantioselective synthesis of ( R)-4-piperidinylglycine

An efficient process for the synthesis of ( R)- N- t-Boc-4-piperidinylglycine 8a, an unnatural amino acid, via enantioselective rhodium-catalyzed hydrogenation of the Cbz-enamide 5a is described. Subsequent deprotection of 8a affords unprotected ( R)-4-piperidinylglycine 9 in good yield. 4

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Bibliographic Details
Published in:Tetrahedron: asymmetry 2001-09, Vol.12 (17), p.2421-2425
Main Authors: Shieh, Wen-Chung, Xue, Song, Reel, Noela, Wu, Raeann, Fitt, John, Repič, Oljan
Format: Article
Language:English
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Summary:An efficient process for the synthesis of ( R)- N- t-Boc-4-piperidinylglycine 8a, an unnatural amino acid, via enantioselective rhodium-catalyzed hydrogenation of the Cbz-enamide 5a is described. Subsequent deprotection of 8a affords unprotected ( R)-4-piperidinylglycine 9 in good yield. 4
ISSN:0957-4166
1362-511X
DOI:10.1016/S0957-4166(01)00425-6