Enantioselective oxidation of (±)-2-phenyl-1-propanol to ( S)-2-phenyl-1-propionic acid with Acetobacter aceti: influence of medium engineering and immobilization

The enantioselective oxidation of ( RS)-2-phenyl-1-propanol to ( S)-2-phenylpropionic acid catalysed by Acetobacter aceti occurred under very mild conditions. The rate, substrate tolerance and enantioselectivity (enantiomeric ratio, E >200) can be increased dramatically simply by adding cyclodext...

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Bibliographic Details
Published in:Tetrahedron: asymmetry 2002-10, Vol.13 (21), p.2345-2349
Main Authors: Gandolfi, Raffaella, Borrometi, Antonella, Romano, Andrea, Sinisterra Gago, José V., Molinari, Francesco
Format: Article
Language:English
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Summary:The enantioselective oxidation of ( RS)-2-phenyl-1-propanol to ( S)-2-phenylpropionic acid catalysed by Acetobacter aceti occurred under very mild conditions. The rate, substrate tolerance and enantioselectivity (enantiomeric ratio, E >200) can be increased dramatically simply by adding cyclodextrins to the reaction medium. Cells immobilized in calcium alginate showed good operational stability and good enantioselectivity (e.e. 94%); the catalyst can be re-used at least five times without e.e. diminution. Graphic
ISSN:0957-4166
1362-511X
DOI:10.1016/S0957-4166(02)00641-9