Preparation of ( R)-(−)- and ( S)-(+)-3-hydroxymethyl-1-tetralone tosylates, key intermediates in the synthesis of new CNS drugs, via resolution of precursors

The preparation of ( R)-(−)- and ( S)-(+)-3-hydroxymethyl-1-tetralone tosylates, key intermediates in the synthesis of new CNS drugs in the aminobutyrophenone family, has been developed via classical resolutions or lipase-catalyzed kinetic resolution of one of their precursors. Graphic

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Bibliographic Details
Published in:Tetrahedron: asymmetry 2003-02, Vol.14 (3), p.381-387
Main Authors: Caro, Yolanda, Masaguer, Christian F., Raviña, Enrique
Format: Article
Language:English
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Summary:The preparation of ( R)-(−)- and ( S)-(+)-3-hydroxymethyl-1-tetralone tosylates, key intermediates in the synthesis of new CNS drugs in the aminobutyrophenone family, has been developed via classical resolutions or lipase-catalyzed kinetic resolution of one of their precursors. Graphic
ISSN:0957-4166
1362-511X
DOI:10.1016/S0957-4166(02)00822-4