Stereoselective Michael addition of trimethyl aluminium to nitro acrylates: a route to 2-methyl-3-amino propionic acid

The copper(I)-catalysed Michael addition of trimethyl aluminium to nitro acrylates yields 2-methyl-3-nitro propionic acid esters on a 200 g scale with enantiomeric excesses up to 92%. Graphic

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Bibliographic Details
Published in:Tetrahedron: asymmetry 2003-10, Vol.14 (20), p.3095-3097
Main Authors: Eilitz, Uwe, Leßmann, Frank, Seidelmann, Oliver, Wendisch, Volkmar
Format: Article
Language:English
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Summary:The copper(I)-catalysed Michael addition of trimethyl aluminium to nitro acrylates yields 2-methyl-3-nitro propionic acid esters on a 200 g scale with enantiomeric excesses up to 92%. Graphic
ISSN:0957-4166
1362-511X
DOI:10.1016/S0957-4166(03)00575-5