Preparation of polyfunctional phosphines using zinc organometallics

The reaction of functionalized diorganozincs with chlorodiorganophosphines provides polyfunctional phosphines in good yields. Especially attractive is the hydroboration/boron-zinc exchange sequence which allows the conversion of functionalized olefins into polyfunctional phosphines in a one-pot proc...

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Bibliographic Details
Published in:Tetrahedron: asymmetry 1997-03, Vol.8 (5), p.715-738
Main Authors: Langer, Falk, Püntener, Kurt, Stürmer, Rainer, Knochel, Paul
Format: Article
Language:English
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Summary:The reaction of functionalized diorganozincs with chlorodiorganophosphines provides polyfunctional phosphines in good yields. Especially attractive is the hydroboration/boron-zinc exchange sequence which allows the conversion of functionalized olefins into polyfunctional phosphines in a one-pot procedure. Several new chiral phosphines have been prepared starting from readily available chiral olefins (terpenes) and their efficiency in asymmetric hydrogenation reactions has been evaluated. The reaction of functionalized diorganozincs with chlorodiorganophosphines provides polyfunctional phosphines in good yields. Several new chiral phosphines have been prepared starting from readily available chiral olefins (terpenes) and their efficiency in asymmetric hydrogenation reactions has been evaluated.
ISSN:0957-4166
1362-511X
DOI:10.1016/S0957-4166(97)00027-X