A computer program for analysis, simulation and optimization of asymmetric catalytic processes proceeding through two consecutive steps. Type 1: asymmetrization-kinetic resolutions

A computer program for the treatment of the kinetics of asymmetric catalytic reactions proceeding through two consecutive steps was developed. This allows analysis, simulation and optimization of processes consisting of a sequential (i) asymmetrization of a bifunctional prochiral or meso-compound in...

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Bibliographic Details
Published in:Tetrahedron: asymmetry 1997-10, Vol.8 (19), p.3251-3261
Main Authors: Kroutil, W., Kleewein, A., Faber, K.
Format: Article
Language:English
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Summary:A computer program for the treatment of the kinetics of asymmetric catalytic reactions proceeding through two consecutive steps was developed. This allows analysis, simulation and optimization of processes consisting of a sequential (i) asymmetrization of a bifunctional prochiral or meso-compound in a first step, followed by (ii) kinetic resolution of the chiral intermediate in a second step. A case study shows that—provided that the kinetics of both steps are matching—step two may considerably contribute to the asymmetrization reaction. A computer program for the analysis, simulation and optimization of asymmetric catalytic processes proceeding through two consecutive steps, i.e. sequential (i) asymmetrization of a bifunctional prochiral or meso-compound, followed by (ii) kinetic resolution of the chiral intermediate was developed.
ISSN:0957-4166
1362-511X
DOI:10.1016/S0957-4166(97)00428-X