A convenient resolution of long-chain alkyl epoxides with Jacobsen's salen(Co)III(OAc) catalysts

Non-racemic terminal long-chain alkyl epoxides are prepared from racemic epoxides and 1 mol% ( R, R)- and ( S,S)-salen(Co)III catalysts following a modified procedure for kinetic resolution. The ee's for all epoxides (C-10, C-12, C-14, C-16, C-18, C-20) exceed 95% and the chemical yields range...

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Bibliographic Details
Published in:Tetrahedron: asymmetry 1998-06, Vol.9 (11), p.1843-1846
Main Authors: Savle, Prashant S, Lamoreaux, Marika J, Berry ‡, John F, Gandour, Richard D
Format: Article
Language:English
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Summary:Non-racemic terminal long-chain alkyl epoxides are prepared from racemic epoxides and 1 mol% ( R, R)- and ( S,S)-salen(Co)III catalysts following a modified procedure for kinetic resolution. The ee's for all epoxides (C-10, C-12, C-14, C-16, C-18, C-20) exceed 95% and the chemical yields range from 85% to 95%.
ISSN:0957-4166
1362-511X
DOI:10.1016/S0957-4166(98)00175-X