Guest-induced conformational change in a flexible host: mono- altro-β-cyclodextrin

Mono- altro-β-cyclodextrin 1, a β-cyclodextrin with one of the seven glucose units being configurationally changed to an altrose, is shown to be a flexible host undergoing a distinct conformational change within its altropyranose geometry upon intracavity inclusion of adamantanecarboxylate, thus rep...

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Bibliographic Details
Published in:Tetrahedron: asymmetry 1999-05, Vol.10 (9), p.1689-1696
Main Authors: Fujita, Kahee, Chen, Wen-Hua, Yuan, De-Qi, Nogami, Yasuyoshi, Koga, Toshitaka, Fujioka, Toshihiro, Mihashi, Kunihide, Immel, Stefan, Lichtenthaler, Frieder W
Format: Article
Language:English
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Summary:Mono- altro-β-cyclodextrin 1, a β-cyclodextrin with one of the seven glucose units being configurationally changed to an altrose, is shown to be a flexible host undergoing a distinct conformational change within its altropyranose geometry upon intracavity inclusion of adamantanecarboxylate, thus representing an induced-fit model of binding rather than one following the rigid lock-and-key type pattern.
ISSN:0957-4166
1362-511X
DOI:10.1016/S0957-4166(99)00127-5