Enantioselective addition of diethylzinc to benzaldehyde catalyzed by ferrocenic amino-alcohols combining centered and planar chiralities

Diastereomeric ferrocenic amino-alcohols combining three elements of chirality (one of which is a ferrocenic plane) are tested as catalysts in the alkylation of benzaldehyde with diethylzinc. Good to excellent yields and ees were obtained and show correlation between the metallocenic chirality and t...

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Bibliographic Details
Published in:Tetrahedron: asymmetry 1999-08, Vol.10 (17), p.3253-3257
Main Authors: Malézieux, Bernard, Andrés, Román, Gruselle, Michel, Rager, Marie-Noëlle, Thorimbert, Serge
Format: Article
Language:English
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Summary:Diastereomeric ferrocenic amino-alcohols combining three elements of chirality (one of which is a ferrocenic plane) are tested as catalysts in the alkylation of benzaldehyde with diethylzinc. Good to excellent yields and ees were obtained and show correlation between the metallocenic chirality and the configuration of the resulting 1-phenyl-1-propanol.
ISSN:0957-4166
1362-511X
DOI:10.1016/S0957-4166(99)00307-9