Experimental basis for the prevention of breast cancer

Cancer chemoprevention involves intervention in the carcinogenic process by a natural or synthetic chemical that either blocks neoplasia development or arrests malignant phenotype progression. The chemopreventive test agent must experimentally be established as safe before a clinical trial. In our l...

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Bibliographic Details
Published in:European journal of cancer (1990) 2000-06, Vol.36 (10), p.1275-1282
Main Author: Mehta, R.G
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Carcinogenesis
Carcinogens
Chemopreventive agents
Combination chemoprevention
Female
Mammary lesions
Mammary Neoplasms, Experimental - chemically induced
Mammary Neoplasms, Experimental - pathology
Mammary Neoplasms, Experimental - prevention & control
Mice
Organ culture
Rats
Rats, Sprague-Dawley
Tumor Cells, Cultured
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Summary:Cancer chemoprevention involves intervention in the carcinogenic process by a natural or synthetic chemical that either blocks neoplasia development or arrests malignant phenotype progression. The chemopreventive test agent must experimentally be established as safe before a clinical trial. In our laboratory, inhibition of carcinogen-induced development of precancerous lesions in the mouse mammary gland organ culture model is used as a primary screen to select chemopreventive agents for in vivo efficacy evaluation. A nearly 75% correlation apparently exists between the efficacy observed in vitro and in vivo carcinogenesis. For in vivo experiments, MNU- and DMBA-induced mammary tumours in rats are the models of choice. Numerous agents have been identified and progressed to preclinical toxicity and clinical trials. More recently, combination chemoprevention has received considerable attention, since no known chemopreventive agent sufficiently reduces tumour incidence in rats. The sequence of events for establishing the experimental basis for chemoprevention of breast cancer is described.
ISSN:0959-8049
1879-0852
DOI:10.1016/S0959-8049(00)00100-3